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Что (кто) такое G protein-coupled inwardly-rectifying potassium channel - определение
G protein-coupled inwardly-rectifying potassium channel
FAMILY OF LIPID-GATED INWARD-RECTIFIER POTASSIUM ION CHANNELS
G protein-coupled inwardly-rectifying potassium channels; GIRK; G protein coupled inward rectifier potassium channel; G protein-activated inward rectifier potassium channel
The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion channels which are activated (opened) by the signaling lipid PIP2 and a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits (Gβγ) from inactive heterotrimeric G protein complexes (Gαβγ).
Inward-rectifier potassium channel
![mV]], and the top-most to +60mV, relative to the [[resting potential]], which is close to the K<sup>+</sup> [[reversal potential]] in this experimental system. Other traces are in 10mV increments between the two.](https://commons.wikimedia.org/wiki/Special:FilePath/Inward-rectification.png?width=200 "mV]], and the top-most to +60mV, relative to the [[resting potential]], which is close to the K<sup>+</sup> [[reversal potential]] in this experimental system. Other traces are in 10mV increments between the two.")
GROUP OF TRANSMEMBRANE PROTEINS THAT PASSIVELY TRANSPORT POTASSIUM IONS
Potassium channels, inwardly rectifying; Inwardly-rectifying potassium channel; Inwardly rectifying potassium channel; Inward potassium rectifier current; Inward rectifier; Inward rectifier kir; Weaver mouse ataxia; Inward rectifier potassium ion channel; Inward rectifier potassium channel; Inward-rectifier K+ channel; Inward-rectifier potassium ion channel
Inward-rectifier potassium channels (Kir, IRK) are a specific lipid-gated subset of potassium channels. To date, seven subfamilies have been identified in various mammalian cell types, plants, and bacteria.
G protein-coupled receptor
![PDB]] entry [https://web.archive.org/web/20180128134132/https://www.rcsb.org/structure/3SN6 3SN6]). The receptor is colored red, Gα green, Gβ cyan, and Gγ yellow. The C-terminus of Gα is located in a cavity created by an outward movement of the cytoplasmic parts of TM5 and 6.](https://commons.wikimedia.org/wiki/Special:FilePath/Beta2Receptor-with-Gs.png?width=200 "PDB]] entry [https://web.archive.org/web/20180128134132/https://www.rcsb.org/structure/3SN6 3SN6]). The receptor is colored red, Gα green, Gβ cyan, and Gγ yellow. The C-terminus of Gα is located in a cavity created by an outward movement of the cytoplasmic parts of TM5 and 6.")
![Proposed downstream interactions between [[integrin]] signaling and GPCRs. Integrins are shown elevating Ca<sup>2+</sup> and phosphorylating FAK, which is weakening GPCR signaling.](https://commons.wikimedia.org/wiki/Special:FilePath/GPCR and itegrin signaling diagram.png?width=200 "Proposed downstream interactions between [[integrin]] signaling and GPCRs. Integrins are shown elevating Ca<sup>2+</sup> and phosphorylating FAK, which is weakening GPCR signaling.")
LARGE PROTEIN FAMILY OF RECEPTORS THAT DETECT MOLECULES OUTSIDE THE CELL AND ACTIVATE INTERNAL SIGNAL TRANSDUCTION PATHWAYS AND CELLULAR RESPONSES
G-protein coupled receptors; G-protein coupled receptor; 7TM receptor; G protein coupled receptor; GPCR; Heptahelical receptor; 7 transmembrane receptor; Seven transmembrane receptor; Seven-transmembrane protein; Seven transmembrane region; G-protein-coupled receptors; Guanine Nucleotide-Binding Protein-Coupled Receptor; 7TM Receptor; 7TM; G-protein-coupled receptor; Receptors, g-protein-coupled; 7-transmembrane G-protein coupled; G-protein coupled; G protein-coupled; 7 transmembrane; 7-transmembrane; G-protein linked receptors; G-protein coupled membrane receptors; G protein-coupled receptors; G-protein-coupled; Serpentine receptor; G protein coupled receptors; Gi coupled receptor; Seven transmembrane protein; 7-transmembrane receptor; Gpcr; Gpcrs; G protein–coupled receptor; GPCRs
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.
